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Home Field Advantage: Intravaginal Immunization May Help Protect Against Infection

Researchers led by John Schiller at the National Cancer Institute have published a study exploring the immune response to intravaginal immunization in mice infected with a strain of the HPV virus carrying a certain antigen. The researchers found that intravaginal immunization significantly increased the number of immune cells present in the vaginal mucosa as compared to a general immune system booster. The results show that area-specific vaccination enhances the local immune system response and may be helpful in developing STD vaccines. The study titled,'Intravaginal Immunization with HPV Vectors Induces Tissue-Resident CD8+ T cell Responses' is published online in the Journal of Clinical Investigation (2012; doi:10.1172/JCI63287).
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Disclaimer: NPIN provides this information as a public service only. The views and information provided about the materials, funding opportunities, and organizations do not necessarily state or reflect those of the U.S. Department of Health and Human Services, CDC, or NPIN. News Record #60729

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