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Male Circumcision and Genital Human Papillomavirus: A Systematic Review and Meta-Analysis

HPV is the leading cause of invasive cervical cancer, and some evidence suggests that male circumcision (MC) may protect against this infection and related disease in both men and women. The authors undertook the current study to assess the association between MC and genital HPV infection indicators, including genital warts. They conducted a systematic search of Medline to identify all relevant studies from February 1971 to August 2010. Effect estimates were included in random effects models. The meta-analysis included 21 studies with 8,046 circumcised and 6,336 uncircumcised men. “MC was associated with a statistically significant reduced odds of genital HPV prevalence (odds ratio=0.57, 95 percent confidence interval: 0.42-0.77),” the authors found. This association was seen as well for genital high-risk HPV prevalence in two randomized controlled trials (OR=0.67, 95 percent CI: 0.54-0.82). The team found no associations between MC and genital HPV acquisition of new infections, genital HPV clearance or genital warts. “This meta-analysis shows a robust inverse association between MC and genital HPV prevalence in men,” the authors concluded. “However, more studies are needed to adequately assess the effect of MC on the acquisition and clearance of HPV infections. MC could be considered as an additional one-time preventative intervention likely to reduce the burden of HPV-related diseases both in men and women, particularly among those countries in which HPV vaccination programs and cervical screening are not available.”
Date of Publication
Ginesa Albero; Xavier Castellsagué; Anna R. Giuliano; Francesc Xavier Bosch
Article Type
Article Category
Medical News

Disclaimer: NPIN provides this information as a public service only. The views and information provided about the materials, funding opportunities, and organizations do not necessarily state or reflect those of the U.S. Department of Health and Human Services, CDC, or NPIN. News Record #59217

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