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Rapid Decline in Presentations of Genital Warts After the Implementation of a National Quadrivalent Human Papillomavirus Vaccination Program for Young Women
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Abstract
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| Australia has provided free quadrivalent HPV vaccine to 12- to 18-year-old girls through a school-based program since April 2007 and to women age 26 and younger through general medical practices since July 2007. To determine if the program has had a population impact on presentations of genital warts, the researchers undertook a retrospective study comparing the proportion of new clients with genital warts attending Melbourne Sexual Health Center from January 2004 to December 2008.
During the study period, the center saw 36,055 new clients and 3,826 were diagnosed with genital warts (10.6 percent; 95 percent confidence interval [CI] 10.3 to 10.9). The proportion of women younger than 28 diagnosed with warts fell by 25.1 percent (95 percent CI 30.5 percent to 19.3 percent) per quarter in 2008. Comparing this decline to a negligible increase of 1.8 percent (95 percent CI 0.2 percent to 3.4 percent) per quarter from the start of 2004 to the end of 2007, also in women under 28, generates strong evidence of a difference in these two trends (p less than 0.001).
“There was no evidence of a difference in trend for the quarterly proportions before and after the end of 2007 for any other subgroup, and on only one occasion was there strong evidence of a trend different to zero, for heterosexual men in 2008 in whom the average quarterly change was a decrease of 5 percent (95 percent CI 0.5 percent to 9.4 percent; p=0.031).
“The data suggest that a rapid and marked reduction in the incidence of genital warts among vaccinated women may be achievable through an HPV vaccination program targeting women, and supports some benefit being conferred to heterosexual men,” the authors concluded.
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Author
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| C.K. Fairley; J.S. Hocking; L.C. Gurrin; M.Y. Chen; B. Donovan; C.S. Bradshaw |
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Subjects
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Disease Prevention
HPV
Program Evaluation
Sexually Transmitted Diseases (STDs)
Studies or Surveys
Vaccines
Women
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cdcnpin.org News Record #54714
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