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Facts and Fiction of the Relationship Between Pre-existing Tuberculosis and Lung Cancer Risk: A Systematic Review
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Abstract
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| The authors introduced the current study by acknowledging the existence of “conflicting evidence” regarding the possible association between TB and subsequent risk of lung cancer. To investigate, they undertook a systematic review of 37 case-control studies and four cohort studies (published between January 1966 and January 2009) and a meta-analysis of risk estimates - with particular attention to the role of smoking, passive smoking, and the timing of TB diagnosis - on this relationship.
“Data for the review show a significantly increased lung cancer risk associated with pre-existing TB,” the researchers wrote. Of note was the fact that the association was not due to confounding by the effects of tobacco use (RR=1.8, 95 percent confidence interval [CI]=1.4-2.2, among never-smoking individuals), lifetime environmental tobacco smoke exposure (RR=2.9, 95 percent CI=1.6-5.3, after controlling) or the timing of TB diagnosis (the increased lung cancer risk remained two-fold elevated for more than 20 years after TB diagnosis).
The researchers found this association to be significant with adenocarcinoma (RR=1.6, 95 percent CI=1.2-2.1), but no significant associations were observed with squamous and small-cell type lung cancer.
“Although no causal mechanism has been demonstrated for such an association, present study supports a direct relation between TB and lung cancer, especially adenocarcinomas,” the authors concluded.
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Author
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| Hui-Ying Liang; Xue-Lian Li; Xiao-Song Yu; Peng Guan; Zhi-Hua Yin; Qin-Cheng He; Bao-Sen Zhou
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Subjects
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Cancer
Risk Assessment
Studies or Surveys
Tuberculosis (TB)
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cdcnpin.org News Record #54306
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