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Extracellular Vesicles in HIV/AIDS and Substance Abuse (R01)

Grant Amount: NIDA intends to commit $2 million in FY2015 to fund a combined total of 6-9 R21 and R01 awards.

The purpose of this FOA is to encourage research projects that investigate extracellular vesicles in HIV infection/progression or as potential HIV/AIDS biomarkers or therapeutics. Proposed projects must also explore the potential impact of exposure to substances of abuse.

Proposed projects MUST include the following: 1) the major thrust of the application should involve extracellular vesicles or associated secretory machinery, 2) at least one aim must investigate a significant question in HIV/SIV biology, and 3) at least one aim or sub-aim must involve exposure to substances of abuse, or analysis of samples from patients exposed to a drug of abuse. Substances of abuse of interest include: nicotine, cocaine, stimulants, opioids, abused prescription drugs, cannabinoids, or combinations of these drugs. Applications lacking any of the these aspects will not be considered responsive to this FOA and will not proceed to review. Applications focused solely on alcohol exposure could consider applying via PA-13-197. NIDA anticipates publishing an FOA in 2016 specifically focused on the topic of EVs in substance abuse and neuroplasticity.

RFA-DA-15-011 uses the R01 grant mechanism while RFA-DA-15-012 uses the R21 mechanism. High risk/high payoff projects that lack significant preliminary data are most appropriate for the R21 mechanism, while applicants with significant preliminary data may wish to apply using the R01 mechanism.

Funding Organization
National Institute on Drug Abuse
Fund Category
Support Types
Eligible Organizations
City Agencies
Commercial Organizations
Community Based Organizations
County Agencies
Educational Organizations/Institutions
Federal Government Agencies
International Agencies
IRS 501 (c)(3) Organizations
Nonprofit Organizations
Religious Organizations
State Agencies
Tribal Organizations
Award Amount Notes
NIDA intends to commit $2 million in FY2015 to fund a combined total of 6-9 R21 and R01 awards.
Letter of Intent Date
Application Due Date
Project Start Date
Application Contact
Phone: (301) 435-0714
Technical Contact
John Satterlee
Phone: (301) 435-1020
Fund Duration
Up to 5 years.
Drug Abuse
Medical Treatments and Therapies
Research Programs
Substance Abuse Treatment and Counseling
Application Process
Applicants must download the SF424 (R&R) application package associated with this funding opportunity using the “Apply for Grant Electronically” button in this FOA or following the directions provided at

It is critical that applicants follow the instructions in the SF424 (R&R) Application Guide (, including Supplemental Grant Application Instructions except where instructed in this funding opportunity announcement to do otherwise. Conformance to the requirements in the Application Guide is required and strictly enforced. Applications that are out of compliance with these instructions may be delayed or not accepted for review.
Companion Funding Opportunity: RFA-DA-15-012, R21 Exploratory/Developmental Grant.
Web Site
Fund Number

Disclaimer: NPIN provides this information as a public service only. The views and information provided about the materials, funding opportunities, and organizations do not necessarily state or reflect those of the U.S. Department of Health and Human Services, CDC, or NPIN. Fund Record #4858

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