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Strengthening Adherence to Antiretroviral-Based HIV Prevention and Treatment (R01)

Grant Amount: Unspecified.

This Funding Opportunity Announcement (FOA) encourages research to understand and promote adherence to antiretroviral (ARV) regimens for HIV treatment and prevention. Studies addressing pre-exposure prophylaxis (PrEP) and antiretroviral therapy (ART) are the foci of this FOA. The overarching emphasis is on the development of feasible interventions to improve and sustain PrEP or ART adherence which could be rapidly implemented in clinical, community, and policy environments to improve HIV treatment and prevention outcomes.

A well-articulated theoretical or conceptual framework is essential in all applications submitted to this announcement. Approaches based on basic behavioral and social scientific concepts such as cognition, emotion, motivation, communication, developmental approaches, social interaction, decision-making, behavioral economics, and structural models are invited. Any descriptive studies should be undertaken with the aim of informing the design or mechanisms of adherence interventions. Interventions should be appropriately tailored to relevant U.S. domestic and foreign populations, and may target individuals, providers, social networks, healthcare clinics, communities, or other groups.

In HIV treatment, ART adherence represents one element of the wider HIV care continuum. Research applications primarily addressing aspects of the HIV care continuum other than ART adherence, such as HIV diagnosis and care engagement, may consider the priorities identified in PA-14-130 and PA-14-132, "Accelerating Improvements in the HIV Care Continuum."

Funding Organization
National Institute of Allergy and Infectious Diseases
Division of AIDS
US Department of Health and Human Services
Public Health Services
National Institutes of Health
National Institute of Mental Health
Fund Category
Support Types
Eligible Organizations
City Agencies
Commercial Organizations
Community Based Organizations
County Agencies
Educational Organizations/Institutions
Federal Government Agencies
International Agencies
IRS 501 (c)(3) Organizations
Nonprofit Organizations
Religious Organizations
State Agencies
Tribal Organizations
Award Amount Notes
The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications.
Application Due Date
Project Start Date
Application Contact
Phone: (301) 435-0714
Technical Contact
Michael J Stirratt
Phone: (301) 443-6802
Fund Duration
Up to 5 years.
Antiretroviral Drugs
HIV/AIDS Prevention
Medical Treatments and Therapies
Research Programs
Application Process
Applicants must download the SF424 (R&R) application package associated with this funding opportunity using the “Apply for Grant Electronically” button in this FOA or following the directions provided at

It is critical that applicants follow the instructions in the SF424 (R&R) Application Guide (, except where instructed in this funding opportunity announcement to do otherwise. Conformance to the requirements in the Application Guide is required and strictly enforced. Applications that are out of compliance with these instructions may be delayed or not accepted for review.
Companion Funding Opportunity: PA-14-125, R21 Exploratory/Developmental Grant.
Web Site
Fund Number

Disclaimer: NPIN provides this information as a public service only. The views and information provided about the materials, funding opportunities, and organizations do not necessarily state or reflect those of the U.S. Department of Health and Human Services, CDC, or NPIN. Fund Record #4817

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