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Targeted Basic Behavioral and Social Science and Intervention Development for HIV Prevention and Care (R21)

Grant Amount: Unspecified.

This Funding Opportunity Announcement (FOA) provides a global outline of areas for innovative, targeted basic behavioral and social science research and intervention development research to reduce the number of new HIV infections and improve the overall health of those living with HIV that we intend to fund. This FOA encourages research designed to (a) conduct basic behavioral and social science research that is needed to advance the development of HIV prevention and care interventions, (b) translate and operationalize the findings from these basic studies to develop interventions and assess their feasibility and (c) conduct tests of the efficacy of HIV prevention and care interventions. This FOA is informed by priority areas from the National HIV/AIDS Strategy for the United States and the NIH Office of AIDS Research (OAR) Strategic Plan for HIV/AIDS Related Research.

This FOA encourages novel, high impact behavioral and social science research that will contribute to the creation of empirically-based HIV-risk reduction approaches that could be used to pave the way for prevention, reduction of clinical impact, and cure. High impact can be achieved either by large effect size or very broad reach. This FOA outlines the following aims to achieve these goals: (1) conduct targeted basic behavioral and social science research to identify and quantify both micro- and macro-level social and behavioral determinates that mediate or moderate HIV acquisition, transmission and care, (2) advance combination behavioral-biomedical approaches to HIV-related interventions, (3) increase intervention potency and durability, (4) enhance targeting on those most highly impacted by the pandemic, (5) identify novel intervention approaches and methodologies and (6) target multiple levels of influence on HIV acquisition, transmission, and care, thereby advancing the development and testing of interventions delivered beyond the individual level (structural, community, social/sexual networks, etc).

The R21 mechanism is specifically intended to encourage new exploratory and developmental research projects. These studies should break new ground or extend previous discoveries toward new directions or applications. These studies may involve considerable risk but may lead to a breakthrough in a particular area, or to the development of novel methodologies, tools, technologies, or interventions that could have a major impact on health research and practice. Unlike applications under the R01 mechanism, preliminary data are not required for R21 applications. Preliminary data may nonetheless be included if available.

This FOA focuses on basic behavioral and social science research only. Applicants with a focus on NeuroAIDS are referred to HIV Infection of the Central Nervous System (PA-14-094) and Eradication of HIV from central nervous system reservoirs (PA-14-095).
Funding Organization
National Institute of Allergy and Infectious Diseases
Division of AIDS
US Department of Health and Human Services
Public Health Services
National Institutes of Health
National Institute of Mental Health
Fund Category
Support Types
Eligible Organizations
City Agencies
Commercial Organizations
Community Based Organizations
County Agencies
Educational Organizations/Institutions
Federal Government Agencies
International Agencies
IRS 501 (c)(3) Organizations
Nonprofit Organizations
Religious Organizations
State Agencies
Tribal Organizations
Award Amount Notes
The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications.
Application Due Date
Project Start Date
Application Contact
Phone: (301) 435-0714
Technical Contact
Pim Brouwers
Phone: (301) 443-6100
Fund Duration
Up to 2 years.
Behavioral Research
Health Care Programs/Services
HIV/AIDS Prevention
Persons with HIV/AIDS
Social Services
Application Process
Applicants must download the SF424 (R&R) application package associated with this funding opportunity using the “Apply for Grant Electronically” button in this FOA or following the directions provided at

It is critical that applicants follow the instructions in the SF424 (R&R) Application Guide (, except where instructed in this funding opportunity announcement to do otherwise. Conformance to the requirements in the Application Guide is required and strictly enforced. Applications that are out of compliance with these instructions may be delayed or not accepted for review.
Companion Funding Opportunity: PA-14-127, R01 Research Project Grant.
Web Site
Fund Number

Disclaimer: NPIN provides this information as a public service only. The views and information provided about the materials, funding opportunities, and organizations do not necessarily state or reflect those of the U.S. Department of Health and Human Services, CDC, or NPIN. Fund Record #4813

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