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Substance Use and Abuse, Risky Decision Making and HIV/AIDS (R21)

Grant Amount: Unspecified.

This Funding Opportunity Announcement (FOA) is intended to stimulate model-driven research to understand the ways that people make decisions about engaging in behaviors that impact the risk of acquiring or transmitting HIV, or to adhere to treatments for HIV. Decision making processes may contribute to both substance use/abuse and other HIV acquisition or transmission risks. A better understanding of decision making processes in the context of brain neural networks and their associated functions would lead to the development of better strategies to reduce the frequency of HIV-risk behaviors. Therefore, this FOA encourages applications to study (1) cognitive, motivational or emotional mechanisms and/or (2) brain neuroendocrine and reinforcement systems that are related to HIV-risk behaviors or treatment non-compliance. Interdisciplinary studies that incorporate approaches from psychology, economics, anthropology, sociology, decision sciences, neuroscience and computational modeling are encouraged. This FOA for R21 applications is intended to encourage exploratory and developmental research projects by providing support for the early and conceptual stages of these projects. These studies may involve considerable risk but may lead to a breakthrough in a particular area, or to the development of novel techniques, agents, methodologies, models, or applications that could have a major impact.

This FOA encourages R21 applications that will employ experimental measures or manipulations in human laboratory settings to better characterize and understand poor decision making and risky behavior as they relate to HIV/AIDS and substance use/abuse. The R21 activity code is intended to foster the introduction of novel scientific ideas, model systems, tools, agents, targets, and technologies that have the potential to substantially advance biomedical research. This FOA is intended to encourage new exploratory and developmental research projects. For example, such projects could assess the feasibility of a novel area of investigation or a new experimental system that has the potential to enhance health-related research. Another example could include the unique and innovative use of an existing methodology to explore a new scientific area. These studies may involve considerable risk but may lead to a breakthrough in a particular area, or to the development of novel techniques, agents, methodologies, models, or applications that could have a major impact on a field. Studies that involve individuals living with HIV or persons who are recognized to be at high risk of acquiring HIV are strongly encouraged. Studies may examine behaviors, attitudes or underlying brain processes in that increase the risk of acquiring or transmitting HIV (e.g. unprotected sexual activity) or decrease adherence to ARV regimens. Investigators conducting research on the natural history and epidemiology, prevention, services or treatment aspects of drug or alcohol abuse and HIV/AIDS should refer to the NIDA or NIAAA FOAs directed at those areas (;

Funding Organization
National Institute on Drug Abuse
US Department of Health and Human Services
Public Health Service
National Institutes of Health
National Institute on Alcohol Abuse and Alcoholism
Fund Category
Support Types
Eligible Organizations
City Agencies
Commercial Organizations
Community Based Organizations
County Agencies
Educational Organizations/Institutions
Federal Government Agencies
IRS 501 (c)(3) Organizations
Nonprofit Organizations
Religious Organizations
State Agencies
Tribal Organizations
Award Amount Notes
The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications.

Direct Costs maximum of $275,000 over two years with no more than $200,000 in either year.

Application Due Date
Project Start Date
Application Contact
Phone: (301) 435-0714
Technical Contact
Yu (Woody) Lin
Phone: (301) 435-1318
Fund Duration
Up to 2 years.
Behavioral Research
High Risk Behaviors
HIV/AIDS Prevention
Medical Treatments and Therapies
Research Programs
Risk Reduction
Substance Abuse Treatment and Counseling
HIV Positive Persons
Persons Practicing High Risk Behaviors
Application Process
Applicants must download the SF424 (R&R) application package associated with this funding opportunity using the “Apply for Grant Electronically” button in this FOA or following the directions provided at

It is critical that applicants follow the instructions in the SF424 (R&R) Application Guide (, except where instructed in this funding opportunity announcement to do otherwise. Conformance to the requirements in the Application Guide is required and strictly enforced. Applications that are out of compliance with these instructions may be delayed or not accepted for review.
Companion Funding Opportunity: PA-14-061, R01 Research Project Grant; PA-14-063, R03 Small Grant Program.

AIDS Application Due Date(s): Standard AIDS dates apply, by 5:00 PM local time of applicant organization. The first AIDS application due date for this FOA is May 7, 2014.
Web Site
Fund Number

Disclaimer: NPIN provides this information as a public service only. The views and information provided about the materials, funding opportunities, and organizations do not necessarily state or reflect those of the U.S. Department of Health and Human Services, CDC, or NPIN. Fund Record #4775

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