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Epidemiology, Prevention, and Treatment of Influenza and Other Respiratory Infections in a Malaria-Endemic Area of Malawi with High HIV Prevalence

Grant Amount: Estimated total funding (direct costs) for the first year (12 month budget period): $1,200,000; Estimated total funding (direct cost) for the entire project period $5,000,000.

The NCIRD Influenza Division (ID) is seeking a cooperative agreement with the University of Liverpool, Liverpool School of Tropical Medicine’s Malawi-Liverpool-Wellcome Trust Clinical Research Programme to strengthen the capacity in Malawi to detect, describe, and conduct studies on influenza and emerging and re-emerging infectious diseases of public health importance and to evaluate new diagnostics, vaccines, and other interventions that may offer approaches toward their prevention or treatment.

The primary objectives of this award are to:
Identify risk factors for severe influenza and other respiratory infections such as age, underlying medical conditions, malnutrition, co-infection with other pathogens, and environmental exposures;
Characterize influenza and other respiratory infections in at-risk populations with different approaches including longitudinal cohort studies (e.g., among pregnant women, children, persons infected with HIV, tuberculosis or malaria);
Evaluate the impact of co-infection with other pathogens on response to influenza vaccination and/or treatment with antivirals;
Evaluate the impact of pneumococcal vaccination (recently introduced in Malawi) on influenza hospitalization;
Evaluate diagnostic tests for influenza and other emerging pathogens, such as multiplex PCR platforms, serological tests, and rapid diagnostic tests.

In addition to the primary objectives, the following additional objectives may also be addressed:
Conduct trials to evaluate influenza vaccine efficacy, effectiveness, cost-effectiveness, and impact of other potential influenza prevention or treatment strategies such as antiviral drugs or statins;
Estimate and characterize influenza-associated mortality using verbal autopsy data and post-mortem respiratory tract sampling;
Estimate direct costs associated with influenza disease and other respiratory infections;
Document health utilization patterns for and caregivers’ recognition and interpretation of pneumonia and other respiratory illnesses;
Document clinical care and prescribing practices for acute lower respiratory tract infections.
Funding Organization
US Department of Health and Human Services
Public Health Service
Centers for Disease Control and Prevention
Fund Category
Support Types
Cooperative Agreements
Eligible Organizations
International Agencies
Number of Awards Given
1 award
Award Amount Notes
Estimated total funding (direct costs) for the first year (12 month budget period): $1,200,000.
Estimated total funding (direct cost) for the entire project period $5,000,000.
Awards issued under this FOA are contingent on the availability of funds and submission of a sufficient number of meritorious applications.
Application Due Date
Project Start Date
Application Contact Customer Support
Phone: (800) 518-4726
Technical Contact
Deborah Loveys
Extramural Rsch Program OfficeNCHHSTP
Ofc of the Assoc Director of Sci
1600 Clifton Road, MS E-60
Atlanta, GA 30333
Phone: (404) 718-8834
Fax: (404) 718-8822
Fund Duration
5 years.
Developing Nations
Disease Prevention
HIV/AIDS Prevention
International Cooperation
Medical Treatments and Therapies
Research Programs
Risk Reduction
Application Process
Applicants must download the SF424 (R&R) application package associated with this funding opportunity from
If access to the Internet is not available or if the applicant encounters difficulty accessing the forms on-line, contact the HHS/CDC Procurement and Grants Office Technical Information Management Section (PGO TIMS) staff at (770) 488-2700 or for further instructions. Hours: Monday - Friday, 7am – 4:30pm U.S. Eastern Standard Time. Closed on Federal Holidays. CDC Telecommunications for the hearing impaired or disabled is available at: TTY 1-888-232-6348.
Web Site
Fund Number

Disclaimer: NPIN provides this information as a public service only. The views and information provided about the materials, funding opportunities, and organizations do not necessarily state or reflect those of the U.S. Department of Health and Human Services, CDC, or NPIN. Fund Record #4765

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