Epidemiology, Prevention, and Treatment of Influenza and Other Respiratory Infections in a Malaria-Endemic Area of Malawi with High HIV Prevalence
Grant Amount: Estimated total funding (direct costs) for the first year (12 month budget period): $1,200,000; Estimated total funding (direct cost) for the entire project period $5,000,000.
The NCIRD Influenza Division (ID) is seeking a cooperative agreement with the University of Liverpool, Liverpool School of Tropical Medicine’s Malawi-Liverpool-Wellcome Trust Clinical Research Programme to strengthen the capacity in Malawi to detect, describe, and conduct studies on influenza and emerging and re-emerging infectious diseases of public health importance and to evaluate new diagnostics, vaccines, and other interventions that may offer approaches toward their prevention or treatment.
The primary objectives of this award are to: Identify risk factors for severe influenza and other respiratory infections such as age, underlying medical conditions, malnutrition, co-infection with other pathogens, and environmental exposures; Characterize influenza and other respiratory infections in at-risk populations with different approaches including longitudinal cohort studies (e.g., among pregnant women, children, persons infected with HIV, tuberculosis or malaria); Evaluate the impact of co-infection with other pathogens on response to influenza vaccination and/or treatment with antivirals; Evaluate the impact of pneumococcal vaccination (recently introduced in Malawi) on influenza hospitalization; Evaluate diagnostic tests for influenza and other emerging pathogens, such as multiplex PCR platforms, serological tests, and rapid diagnostic tests.
In addition to the primary objectives, the following additional objectives may also be addressed: Conduct trials to evaluate influenza vaccine efficacy, effectiveness, cost-effectiveness, and impact of other potential influenza prevention or treatment strategies such as antiviral drugs or statins; Estimate and characterize influenza-associated mortality using verbal autopsy data and post-mortem respiratory tract sampling; Estimate direct costs associated with influenza disease and other respiratory infections; Document health utilization patterns for and caregivers’ recognition and interpretation of pneumonia and other respiratory illnesses; Document clinical care and prescribing practices for acute lower respiratory tract infections.
US Department of Health and Human Services Public Health Service Centers for Disease Control and Prevention
Number of Awards Given
Award Amount Notes
Estimated total funding (direct costs) for the first year (12 month budget period): $1,200,000. Estimated total funding (direct cost) for the entire project period $5,000,000. Awards issued under this FOA are contingent on the availability of funds and submission of a sufficient number of meritorious applications.
Application Due Date
Project Start Date
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