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Methods for Prevention Packages Program III (MP3 III) (R01)

Grant Amount: Unspecified.

This Funding Opportunity Announcement (FOA) is intended to encourage collaborations between behavioral and biomedical clinical scientists, epidemiologists, mathematical modelers, and clinical trial design specialists to develop new research strategies and methodologies that will facilitate the design and testing of combination HIV prevention interventions (prevention packages).

The purpose of this FOA is to invite applications for multidisciplinary research programs that address two objectives: (1) to devise optimal HIV prevention packages for specific populations, and (2) to perform feasibility and acceptability studies to demonstrate that the prevention package is acceptable to the target population and the study design proposed is appropriate and feasible. The proposed prevention package must include both biomedical and behavioral interventions and interventions to optimize adherence and minimize disinhibition (risk compensation). It is expected that teams conducting this research will perform a systematic review and meta-analysis of existing prevention research data germane to the target population chosen. These data can be used to develop a required mathematical model to assess the impact of various combinations of interventions which have been shown to reduce HIV incidence in the same or similar settings. Populations selected may be a specific high-risk group, such as Native Americans in the U.S. or MSM in high incidence settings. Populations that are most affected by the epidemic in a given setting (e.g., adolescents < 16 years old in Sub Saharan Africa) are strongly encouraged. This research will require a team approach with expertise in behavioral and biomedical methods of HIV prevention, epidemiology, mathematical modeling, and clinical trial design and implementation.

Note: This FOA will only support clinical studies which examine the feasibility and acceptability of a combination prevention intervention in a specific population. Applications proposing clinical trials to measure efficacy of a proposed intervention are not sought through this FOA and will not be supported.

Funding Organization
National Institute of Allergy and Infectious Diseases
Division of Intramural Research
US Department of Health and Human Services
Public Health Services
National Institutes of Health
National Institute of Mental Health
Fund Category
Support Types
Eligible Organizations
City Agencies
Commercial Organizations
Community Based Organizations
County Agencies
Educational Organizations/Institutions
Federal Government Agencies
International Agencies
IRS 501 (c)(3) Organizations
Nonprofit Organizations
Religious Organizations
State Agencies
Tribal Organizations
Award Amount Notes
The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications.

Application budgets are not limited, but need to reflect the actual needs of the proposed project.

Application Due Date
1/7/2016 -- LOI: 30 days before the application due date
Project Start Date
Application Contact
Phone: (301) 435-0714
Technical Contact
Vanessa Elharrar
Phone: (301) 827-0845
Fund Duration
Up to 4 years.
Clinical Research
Epidemiological Research
HIV/AIDS Prevention
Program Development
Research Programs
Application Process
Applicants must download the SF424 (R&R) application package associated with this funding opportunity using the “Apply for Grant Electronically” button in this FOA or following the directions provided at

It is critical that applicants follow the instructions in the SF424 (R&R) Application Guide (, except where instructed in this funding opportunity announcement to do otherwise. Conformance to the requirements in the Application Guide is required and strictly enforced. Applications that are out of compliance with these instructions may be delayed or not accepted for review.
Web Site
Fund Number

Disclaimer: NPIN provides this information as a public service only. The views and information provided about the materials, funding opportunities, and organizations do not necessarily state or reflect those of the U.S. Department of Health and Human Services, CDC, or NPIN. Fund Record #4744

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