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Increased Knowledge and Innovative Strategies to Reduce HIV Incidence–iKnow Projects (R01)

Grant Amount: Unspecified.

The purpose of this FOA is to promote innovative research that addresses one or both of the following objectives:

(1) Devise optimal strategies to improve the identification of persons unaware of their HIV-1 infection and successfully link them to HIV testing, treatment, and prevention interventions;
(2) Develop and examine the feasibility and acceptability of novel integrated interventions of biomedical and behavioral strategies that substantially reduce the likelihood of onward HIV transmission in these populations.

The intent of this announcement is to support the development of innovative strategies to identify persons unaware of their HIV infection in specific high-risk populations and settings on an ongoing basis. The populations selected should be documented to be at high risk of HIV infection and have a high proportion that do not know their HIV status. This would include, for example, young African American men who have sex with men in the U.S., and adolescent women in South Africa.

Applications that propose research in the United States are encouraged to propose research with high-risk populations that contain a proportion of persons undiagnosed with HIV-1 that is higher than the national average as defined by the Centers for Disease Control and Prevention. Applications are also encouraged to address research in locales that have not received intensive HIV testing outreach in the past three to five years.

Specific areas of research interest include, but are not limited to:

Social, sexual or drug use network research to characterize groups with individuals that are unaware of their HIV infection;
Interventions to increase screening and testing for persons unaware of their HIV infection, including persons with acute HIV infection;
Phylogenetic studies to characterize persons unaware of their HIV infection and estimate the basic reproductive number of disease, R0, in specific populations;
Mathematical modeling of strategies to reduce HIV incidence in these populations;
Clinical studies to determine feasibility and acceptability (up to Phase IIA) of novel interventions in these populations.
Funding Organization
National Institute of Allergy and Infectious Diseases
National Institute on Drug Abuse
Division of Intramural Research
US Department of Health and Human Services
Public Health Services
National Institutes of Health
National Institute of Mental Health
Fund Category
Support Types
Eligible Organizations
City Agencies
Commercial Organizations
Community Based Organizations
County Agencies
Educational Organizations/Institutions
Federal Government Agencies
International Agencies
IRS 501 (c)(3) Organizations
Nonprofit Organizations
Religious Organizations
State Agencies
Tribal Organizations
Award Amount Notes
The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications.
Application budgets are not limited, but need to reflect the actual needs of the proposed project.

Application Due Date
Project Start Date
Application Contact
Phone: (301) 435-0714
Technical Contact
David Burns
Phone: (301) 435-8896
Fund Duration
Up to 5 years.
Clinical Research
HIV Testing
HIV/AIDS Prevention
Medical Treatments and Therapies
Research Programs
At Risk Persons
HIV Positive Persons
Application Process
Applicants must download the SF424 (R&R) application package associated with this funding opportunity using the “Apply for Grant Electronically” button in this FOA or following the directions provided at

It is critical that applicants follow the instructions in the SF424 (R&R) Application Guide (, except where instructed in this funding opportunity announcement to do otherwise. Conformance to the requirements in the Application Guide is required and strictly enforced. Applications that are out of compliance with these instructions may be delayed or not accepted for review.
Web Site
Fund Number

Disclaimer: NPIN provides this information as a public service only. The views and information provided about the materials, funding opportunities, and organizations do not necessarily state or reflect those of the U.S. Department of Health and Human Services, CDC, or NPIN. Fund Record #4743

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