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Structural Interventions, Alcohol Use, and Risk of HIV/AIDS (R21)

Grant Amount: Unspecified.

By using the R21 mechanism, the NIAAA seeks to foster the introduction of novel scientific ideas, model systems, tools, agents, targets, and technologies that have the potential to substantially advance biomedical research. Applications for R21 awards should describe projects distinct from those supported through the traditional R01 mechanism. For example, long-term projects, or projects designed to increase knowledge in a well-established area, will not be considered for R21 awards. Applications submitted under this mechanism should be exploratory and novel. These studies should break new ground or extend previous discoveries toward new directions or applications.

This FOA requests research on the effectiveness of structural interventions that reduce the risk of HIV/AIDS transmission by changing the environment of alcohol use. Although a variety of structural and environmental interventions have been employed successfully to reduce other drinking-related problems, there has been relatively little research that extends such efforts into the realm of HIV/AIDS risk reduction. Applicants are especially encouraged to examine the ramifications for HIV/AIDS risk—particularly among high-risk populations for HIV—of “naturally occurring” or already-announced changes in alcohol-related laws, regulations, programs or policies.

This FOA focuses on intermediate-level factors that directly affect the drinking environment. Hence, applications appropriate for this announcement will assess the impacts on HIV/AIDS risk of changes in one or more features of the alcohol consumption environment, including—but not limited to—changes in:

the form of alcohol availability (e.g., the sale of distilled spirits by the individual drink; ban on beer keg sales to individuals);
alcohol server training programs;
access of underage persons to alcohol;
establishment/enforcement of curfews to limit hours of alcohol sales to young people, including restrictions on “happy hours” at alcohol-serving establishments;
alcohol counter-advertising campaigns;
retail prices of alcoholic beverages;
restrictions placed on alcohol advertisements;
enforcement of restrictions on public drinking;
establishment of Employee Assistance Programs implemented at work settings to aid workers in curbing their alcohol use and related problems;
local zoning of alcohol outlets;
screening, assessment, and referral for intervention/treatment for mental disorders, problem drinking, and HIV risk behavior;
physicians’ communication approaches with new HIV-positive patients concerning their alcohol use;
policies and procedures in drinking establishments that affect intoxication levels and/or the likelihood of engaging in subsequent hi-risk sex;
salience of warning labels on antiretroviral medications concerning drinking-associated risks.

The above list is not intended to be exhaustive. Prospective applicants might well consider evaluating a combination of such strategies in their project.

Funding Organization
National Institute of Allergy and Infectious Diseases
Division of Intramural Research
Fund Category
Support Types
Eligible Organizations
City Agencies
Commercial Organizations
Community Based Organizations
County Agencies
Educational Organizations/Institutions
Federal Government Agencies
International Agencies
IRS 501 (c)(3) Organizations
Nonprofit Organizations
Religious Organizations
State Agencies
Tribal Organizations
Award Amount Notes
The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications.

The combined budget for direct costs for the two year project period may not exceed $275,000. No more than $200,000 may be requested in any single year.

Application Due Date
Project Start Date
Application Contact
Phone: (301) 435-0714
Technical Contact
Robert C Freeman
Phone: (301) 443-8820
Fund Duration
Up to 2 years.
Alcohol Abuse
HIV/AIDS Prevention
Research Programs
Risk Reduction
Application Process
Applicants must download the SF424 (R&R) application package associated with this funding opportunity using the “Apply for Grant Electronically” button in this FOA or following the directions provided at

It is critical that applicants follow the instructions in the SF424 (R&R) Application Guide (, except where instructed in this funding opportunity announcement to do otherwise. Conformance to the requirements in the Application Guide is required and strictly enforced. Applications that are out of compliance with these instructions may be delayed or not accepted for review.
For AIDS Application due date, visit:

Companion Funding Opportunity: PA-13-191, R01 Research Project Grant
Web Site
Fund Number

Disclaimer: NPIN provides this information as a public service only. The views and information provided about the materials, funding opportunities, and organizations do not necessarily state or reflect those of the U.S. Department of Health and Human Services, CDC, or NPIN. Fund Record #4700

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