Grand Challenges: TB Vaccine Accelerator Grant Opportunity
Grant Amount: Approximate total cost of $20 million USD over three years.
The TB Vaccine Accelerator, a program to strengthen the pipeline of tuberculosis (TB) vaccine candidates and enable a more rational and accelerated vaccine development process, is launching a grant opportunity that is part of the Grand Challenges in Global Health - a large set of grant programs aimed at overcoming persistent bottlenecks that prevent the creation of effective health solutions for the developing world.
This grant opportunity, the first public request for applications (RFA) launched by the TB Vaccine Accelerator, focuses on two interrelated program goals:
(1) to develop novel approaches to vaccination against Mycobacterium tuberculosis (Mtb), with a particular focus on approaches that aim to induce protection against infection with Mtb; and (2) to develop models of natural Mtb transmission and methods for defining the relevant molecular and biological characteristics of naturally transmitted mycobacteria and their interactions with vertebrate hosts.
Scope of Goal 1: Proposals are invited for projects that pursue hypothesis-driven approaches aimed at developing, or critically informing the development of, novel approaches to vaccination against Mtb. Approaches that aim to induce protection against Mtb infection are of particular interest.
Scope of Goal 2: Through this RFA, the sponsor seeks a portfolio of projects that, in concert, will identify properties of Mtb and conditions of exposure associated with the natural establishment of infection; allow such properties and conditions to be mimicked in optimized models and Mtb to be tracked throughout exposure, elimination, transient, and/or persistent infection; and identify host and/or mycobacterial markers that distinguish among these outcomes. The identification of all critically relevant properties of these natural transmission models could allow for their future duplication in artificial transmission models.
Bill and Melinda Gates Foundation
Commercial Organizations International Agencies IRS 501 (c)(3) Organizations Nonprofit Organizations
Award Amount Notes
Assuming proposals of sufficient merit, this competition is expected to fund several grants for an aggregate total cost of $20 million USD over three years.
Letter of Intent Date
Application Due Date
3/25/2013 -- By or before 01/25/2013 select applicants will be asked to complete a full proposal
Program Development TB Prevention Vaccine Development Research
All applicants must first submit a letter of inquiry (an LOI application). A subset of these applicants will then be asked to submit full proposals. LOIs must be submitted electronically by 11:59am PST on November 26, 2012 using the forms and process described at: http://www.grandchallenges.org/GrantOpportunities/Pages/TBVaccineAccelerator.aspx .
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