The Interplay of Substance Abuse and HIV-1 Infection on Glial Cell Function (R01)
Description
Grant Amount: NIDA intends to commit up to $5 million in total costs in FY 2013 to support meritorious projects solicited through this FOA, RFA-DA-13-010 and a companion FOA, RFA-DA-13-011.
The purpose of this Funding Opportunity Announcement (FOA) is to solicit basic and pre-clinical research applications that study the combined and interactive effects of substance abuse and HIV-1 infection on glial cell biology. It is generally accepted that exposure to drugs of abuse alters neuronal function, yet emerging research suggests that drugs of abuse can disrupt glial cell function, as well. In addition, HIV-1 infection acting through viral and host factors affects glial cell function. This FOA encourages research to characterize the molecular and cellular actions of drugs of abuse and factors elicited by HIV-1 infection, giving emphasis to their additive or synergistic interactions, on glial cell function within the central nervous system (CNS).
The objective of this FOA is to encourage the submission of research applications proposing to study the independent as well as the interactive effects of substances of abuse and HIV-1 infection on glial cell biology. Prior research in this area has largely studied the acute, pharmacological actions of drugs of abuse. A key consideration for applicants is that, in general, chronic exposure to substances of abuse precedes HIV-1 infection. As such, this FOA is particularly interested in applications that are likely to determine whether prior and concurrent substance abuse facilitates or exacerbates the consequences of HIV-1 infection on glial cell function. Therefore, investigators are strongly urged to utilize models of long-term or chronic drug exposure and to consider the consequences of drug-induced plasticity within the nervous system in employing appropriate research models for the study of the consequences between substance abuse and HIV-1 infection on glial cell biology. Given this model, study designs that determine additive or synergistic actions between substances of abuse and HIV-1 infection on glial cell function and biological processes, must consider the roles of host and viral factors generated in response to HIV-1 infection in the context of substance abuse and addictive behaviors.
Funding Organization
National Institute on Drug Abuse
Fund Category
HIV/AIDS
Support Types
Research
Locations
International National
Eligible Organizations
City Agencies Colleges/Universities Commercial Organizations Community Based Organizations County Agencies Educational Organizations/Institutions Federal Government Agencies International Agencies IRS 501 (c)(3) Organizations Nonprofit Organizations Religious Organizations Schools State Agencies Tribal Organizations
Number of Awards Given
6 to 8 awards
Award Amount Notes
NIDA intends to support 6 to 8 R01 applications solicited through this FOA. A companion FOA, RFA-DA-13-011, will support an additional 4 or 5 R21 Exploratory/Developmental Research Grant applications. NIDA intends to commit up to $5 million in total costs in FY 2013 to support meritorious projects solicited through these two FOAs.
Letter of Intent Date
10/19/2012
Application Due Date
11/19/2012
Project Start Date
7/1/2013
Application Contact
Grants.gov Customer Support , Phone: (800) 518-4726
Technical Contact
Diane M Lawrence Associate Director, AIDS Research Program NIDA6001 Executive Boulevard Room 3116, MSC 9581 Bethesda, MD 208929581 Phone: (301) 594-3225 Fax: (301) 594-5610
Fund Duration
Up to 5 years.
Subjects
Drug Abuse HIV Research Programs
Audiences
Researchers
Application Process
Applicants must download the SF424 (R&R) application package associated with this funding opportunity using the “Apply for Grant Electronically” button in this FOA or following the directions provided at Grants.gov.
It is critical that applicants follow the instructions in the SF424 (R&R) Application Guide (http://grants.nih.gov/grants/funding/424/SF424_RR_Guide_General_Adobe_VerB.pdf), except where instructed in this funding opportunity announcement to do otherwise. Conformance to the requirements in the Application Guide is required and strictly enforced. Applications that are out of compliance with these instructions may be delayed or not accepted for review.
Disclaimer: NPIN provides this information as a public service only. The views and information provided about the materials, funding opportunities, and organizations do not necessarily state or reflect those of the U.S. Department of Health and Human Services, CDC, or NPIN.
