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Multicenter AIDS Cohort Study (MACS), Limited Competition (U01)

Total Grant Amounts: NIAID intends to commit $10 to $12 million in total costs in FY 2009.

The Division of AIDS (DAIDS) seeks to fund applications that cover the full scope of needed HIV/AIDS research. Towards that end, DAIDS supports clinical trial networks to address focused questions in selected populations; observational cohorts where highly standardized, quality-assured, and extremely diverse data allow for research beyond standard clinical care in representative populations; and large clinical observational databases such as the North American International Epidemiologic Databases to Evaluate AIDS (IeDEA) network to study HIV outcomes under standard clinical care.

The MACS is a multi-site prospective epidemiology cohort study of men who have sex with men (MSM). Followed since 1983, the cohort is composed of men infected with HIV or at increased risk for such infection. The purpose of this FOA is to continue follow-up of the MACS cohort, the largest cohort study of HIV/AIDS in men in the U.S., thereby supporting studies of the natural and treated history of HIV infection in MSM as well as studies of emerging questions related to long-term HIV infection and treatment. These awards will support ongoing MACS research projects and the initiation of new projects on predictors of response to antiretroviral therapy, including host genomics, and long-term effects of HIV infection, the effects of long-term HIV infection and treatment on the aging process, and the impact of HIV therapy on cardiovascular disease, liver disease, renal disease, neurocognitive impairment, cancer, and other outcomes. Additionally, through the data and specimens collected, MACS awards will provide opportunities for expanded collaborations through independent, investigator-initiated research grants.

This FOA solicits applications from the Center/Coordination, Analysis and Management/MACS (CAMACS) and from each of the four MACS clinical sites. Because the MACS is an ongoing cohort study that has collected data and specimens from cohort participants since 1983, competition will be restricted to the current network of five funded sites. The application from CAMACS will describe the MACS scientific research agenda; it is expected that the principal investigators of all five MACS sites will contribute to the scientific research agenda. Based on that agenda, the CAMACS and clinical site applications will describe how each will support the overall MACS scientific research agenda.

This FOA is funded by the National Institute of Allergy and Infectious Disease (NIAID) and the National Cancer Institute (NCI).

Funding Organization
National Institute of Allergy and Infectious Diseases
National Institutes of Health
Division of AIDS
National Cancer Institute
Office of Communications
Fund Category
Support Types
Cooperative Agreements
Eligible Organizations
Number of Awards Given
up to 5 awards
Award Amount Notes
This initiative is a limited competition Funding Opportunity Announcement (FOA). NIAID intends to commit $10 to $12 million in total costs in FY 2009 to fund up to five MACS awards for a period of 5 years depending on scientific and technical merit as determined by peer review.

Application Due Date
Project Start Date
Application Contact
Mollie Shea
Div of Extramural Activities
Room 2234, MSC-7616
6700-B Rockledge Dr
Bethesda, MD 20892
Phone: (301) 402-6576
Fax: (301) 493-0597
Technical Contact
Robin E Huebner
Division of AIDSRoom 4104, MSC-7626
6700-B Rockledge Dr
Bethesda, MD 208927626
Phone: (301) 402-4239
Fax: (301) 402-3211
Fund Duration
Five years.
Antiretroviral Drugs
Clinical Research
Clinical Trials
Epidemiological Reporting
Long Term Survivors
Medical Treatments and Therapies
Men Who Have Sex with Men
Men Who Have Sex with Men
Application Process
The PHS 398 application instructions are available at in an interactive format. Applicants must use the currently approved version of the PHS 398. For further assistance contact GrantsInfo, Telephone (301) 435-0714, Email:

Telecommunications for the hearing impaired: TTY 301-451-0088.

Applications must have a D&B Data Universal Numbering System (DUNS) number as the universal identifier when applying for Federal grants or cooperative agreements. The D&B number can be obtained by calling (866) 705-5711 or through the web site at The D&B number should be entered on line 11 of the face page of the PHS 398 form.

The title and number of this funding opportunity must be typed on line 2 of the face page of the application form and the YES box must be checked.
Web Site
Fund Number

Disclaimer: NPIN provides this information as a public service only. The views and information provided about the materials, funding opportunities, and organizations do not necessarily state or reflect those of the U.S. Department of Health and Human Services, CDC, or NPIN. Fund Record #3548

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