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Advancing Structural Level Interventions Through Enhanced Understanding of Social Determinants in HIV Prevention and Care (R21)

Grant Amount: Unspecified.

This Funding Opportunity Announcement (FOA) encourages applications that propose to understand and address social determinants associated with the prevention and treatment of HIV. This FOA describes two research endeavors that are unique and overlapping. The first is to characterize those social determinants that are most relevant to HIV prevention and treatment outcomes, particularly in their association with inequities in HIV risk or disease outcomes. The second is to develop and test structural interventions aimed at reducing the negative impact or maximizing positive aspects of social determinants.

The R21 mechanism is specifically intended to encourage new exploratory and developmental research projects. These studies should break new ground or extend previous discoveries toward new directions or applications. These studies may involve considerable risk but may lead to a breakthrough in a particular area, or to the development of novel methodologies, tools, technologies, or interventions that could have an important impact on adherence research or practice. Unlike applications under the R01 mechanism, preliminary data are not required for R21 applications. Preliminary data may nonetheless be included if available.

Broadly, this FOA calls for basic social science and intervention research that aims to:

(1) Identify multi-level factors (individual, familial, societal, economic and legislative) which underlie those social determinants that are associated with risk for HIV acquisition or negative HIV care and treatment outcomes at the individual or population levels. Research that focuses on modifiable factors beyond the individual-level is encouraged.

(2) Identify individual and/or community-level mechanisms (e.g., coping, social networks) associated with desired HIV prevention or HIV disease outcomes despite exposure to negative social, economic and/or legal conditions. Research that operationalizes resilience as distinct from risk factors is particularly encouraged.

(3) Design multi-level, structural interventions to intervene upon specified social determinants or sets of social determinants to minimize the negative effects of those social determinants; attempt to reduce the social and structural barriers that negatively impact HIV risk, care and treatment and go beyond influencing individual knowledge, attitudes, and beliefs. Evidence-based justification (e.g., modeling data) for the design of the structural intervention is encouraged prior to proposing to test its impact on HIV prevention, care and/or treatment outcomes.

Funding Organization
National Institute of Allergy and Infectious Diseases
Division of AIDS
US Department of Health and Human Services
Public Health Services
National Institutes of Health
National Institute of Mental Health
Fund Category
Support Types
Eligible Organizations
City Agencies
Commercial Organizations
Community Based Organizations
County Agencies
Educational Organizations/Institutions
Federal Government Agencies
International Agencies
IRS 501 (c)(3) Organizations
Nonprofit Organizations
Religious Organizations
State Agencies
Tribal Organizations
Award Amount Notes
The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications.
Application Due Date
Project Start Date
Application Contact
Phone: (301) 435-0714
Technical Contact
Cynthia I Grossman
Phone: (301) 443-8962
Fund Duration
Up to 2 years.
HIV/AIDS Prevention
Medical Treatments and Therapies
Patient Care
Policy Development
Research Programs
Application Process
Applicants must download the SF424 (R&R) application package associated with this funding opportunity using the “Apply for Grant Electronically” button in this FOA or following the directions provided at

It is critical that applicants follow the instructions in the SF424 (R&R) Application Guide (, except where instructed in this funding opportunity announcement to do otherwise. Conformance to the requirements in the Application Guide is required and strictly enforced. Applications that are out of compliance with these instructions may be delayed or not accepted for review.
Companion Funding Opportunity: PA-14-133, R01 Research Project Grant.
Web Site
Fund Number

Disclaimer: NPIN provides this information as a public service only. The views and information provided about the materials, funding opportunities, and organizations do not necessarily state or reflect those of the U.S. Department of Health and Human Services, CDC, or NPIN. Fund Record #4822

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