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Sexually Transmitted Infections Cooperative Research Centers (STI CRC) (U19)

Grant Amount: The NIAID intends to commit $11 million total costs in FY 2014 to fund up to five awards.

The purpose of the Sexually Transmitted Infections Cooperative Research Centers (STI CRC) program is to facilitate multidisciplinary, synergistic collaborations that will increase our understanding and further our knowledge of co-infections of two or more specific STIs, as well as the interactions between and among different STI pathogens that may cause or enhance polymicrobial infections of the urogenital tract, e.g., bacterial vaginosis (BV), pelvic inflammatory disease (PID), intraamniotic infection (IAI) and non-gonococcal urethritis (NGU). This collaborative effort is expected to catalyze the discovery of new approaches to prevent, diagnose, and treat co-infections, polymicrobial infections and other clinical outcomes that affect reproductive health.

The objectives of this FOA are to support a group of STI CRCs to engage in a multidisciplinary, diverse set of STI research activities and to encourage new efforts towards understanding co-infections of known STIs, as well as infections that incorporate several pathogens (polymicrobial infections) and present as specific syndromes, for example pelvic inflammatory disease (PID). Basic, translational and/or clinical research is acceptable provided it addresses the purpose of this FOA.

It is anticipated that these efforts will provide insights into the biology of microbes, their interactions with each other, their role in pathogenesis, and their interactions with the host. To this end, the STI CRCs are encouraged to build upon current knowledge, i.e., to utilize data from existing microbiome studies to better define the role of normal flora in STIs; to develop and evaluate control and prevention strategies to reduce the public health impact of STI infections; and to share expertise in order to maintain a vigorous and productive research agenda. An important corollary objective is the training and mentoring of investigators new to the STI field through the establishment and management of pilot Developmental Research Projects.

Topics that would be considered responsive include the study of co-infections, e.g., organisms that present in association with each other or other STIs and are often treated syndromatically versus specifically, as well as polymicrobial infections of the urogenital tract, e.g., bacterial vaginosis (BV), pelvic inflammatory disease (PID), intraamniotic infection (IAI) and non-gonococcal urethritis (NGU).

Funding Organization
National Institute of Allergy and Infectious Diseases
Division of Microbiology and Infectious Diseases
Fund Category
Support Types
Cooperative Agreements
Eligible Organizations
City Agencies
Commercial Organizations
Community Based Organizations
County Agencies
Educational Organizations/Institutions
Federal Government Agencies
IRS 501 (c)(3) Organizations
Nonprofit Organizations
Religious Organizations
State Agencies
Tribal Organizations
Number of Awards Given
Up to 5 awards
Award Amount Notes
The NIAID intends to commit $11 million total costs in FY 2014 to fund up to five awards. Future year amounts may vary depending on annual appropriations.
Letter of Intent Date
Application Due Date
Project Start Date
Application Contact
Phone: (301) 435-0714
Technical Contact
Carolyn Deal
Div of Microbiology & Infectious Diseases

Phone: (301) 402-0443
Fund Duration
Up to 5 years.
Research Programs
Sexually Transmitted Diseases (STDs)
STD Prevention
Application Process
Applicants can access the SF424 (R&R) application package associated with this funding opportunity using the “Apply for Grant Electronically” button in this FOA or following the directions provided at

It is critical that applicants follow the instructions in the SF424 (R&R) Application Guide (, except where instructed in this funding opportunity announcement to do otherwise. Conformance to the requirements in the Application Guide is required and strictly enforced. Applications that are out of compliance with these instructions may be delayed or not accepted for review.
Web Site
Fund Number

Disclaimer: NPIN provides this information as a public service only. The views and information provided about the materials, funding opportunities, and organizations do not necessarily state or reflect those of the U.S. Department of Health and Human Services, CDC, or NPIN. Fund Record #4735

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