Grant Amount: Approximate Total Fiscal Year Funding: $100,000; Approximate Total Project Period Funding: $100,000.
During 2002-2011, CDC assisted with the investigation of 40 tuberculosis (TB) outbreaks involving 647 cases 32 deaths. Early identification and investigation of TB clusters that are likely to become outbreaks has the potential to have a substantial impact on preventing outbreaks by interrupting disease transmission, thereby and making progress toward TB elimination in the United States. Recent research has identified an algorithm to predict which TB genotype clusters are likely to become outbreaks (Althomsons et al, 2012). In order to determine whether it is feasible to develop a national program for intervening with these high-risk clusters and preventing outbreaks, a clear process must be developed for: applying the algorithm using real-world data; performing a comprehensive investigation to identify all persons involved in the cluster; and intervening in the cluster to maximize the number of infected persons that complete treatment. CDC and the awardee of the Cooperative Agreement will collaborate through this feasibility project to develop a process for intervening with small TB clusters that have a high likelihood of becoming outbreaks, thereby preventing outbreaks from occurring. The outcomes of the project will include a report of tools, strategies, and processes that can be used to detect, investigate, and intervene with clusters at high risk of becoming outbreaks (outbreak prevention investigation and intervention process report/protocol) and a written summary of the amount of monetary and personnel resources used to investigate and intervene with the cluster. The four phases (or program strategies) of this feasibility project include cluster detection, cluster investigation, intervention, and documentation/process development; candidate clusters will be included in all phases. A minimum of one and maximum of three candidate clusters will be included. Cluster detection will start at the onset of the project period based on the algorithm published by Althomsons et al (2012); however, the cluster investigation and intervention phases can only start once a candidate cluster has been identified. Therefore, the timelines in this project will be presented in reference to the date of cluster detection rather than the start of the cooperative agreement. The awardee may start with the initial list of specific strategies/activities in the “toolboxes” developed by CDC, but are expected to add to these throughout the course of the project based on own experience and published evidence from the peer-reviewed literature. The awardee is expected to actively work with CDC throughout the process and in development of the products.
US Department of Health and Human Services Public Health Service Centers for Disease Control and Prevention
Number of Awards Given
Award Amount Notes
Approximate Total Fiscal Year Funding: $100,000. Approximate Total Project Period Funding: $100,000.
Application Due Date
Technical Information Management Section DHHS CDC Procurement & Grants Office 2920 Brandywine Road, MS E-14 Atlanta, GA 30341 Phone: (770) 488-2700
Lee A Ramsey Project Officer DHHS/CDCSEOIB/DTBE/NCHHSTP 1600 Clifton Road, MS E-10
Phone: (404) 629-2429
Program Development TB Prevention
Health Planners State Government Agencies
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