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Mechanisms of HIV-Related Lung Disease Data Coordinating Center (DCC) (U01)

Grant Amount: Estimated total of $720,000 for fiscal year 2013, with a total cost commitment of 3.6 million over a 5-year period.

The purpose of this funding opportunity announcement (FOA) is to invite cooperative agreement (U01) applications to participate as the Data Coordinating Center (DCC) for the Mechanisms of HIV-Related Lung Disease program. The DCC will facilitate and support the collaborative activities of the Clinical/Basic research sites which are funded through a companion FOA RFA-HL-13-026.

The Clinical/Basic research focuses on the defining the cellular and molecular events underlying the pathogenesis of HIV-associated lung diseases (e.g., COPD and pulmonary hypertension) using biospecimens and clinical data from HIV-infected patients and controls with an emphasis on clinical translation. The goals are to identify disease sub-phenotypes, potential biomarkers to predict risk, progression, and outcome, and molecular targets to help design therapeutic interventions. The inclusion of multiple Program Director(s)/Principal Investigator(s) (PD(s)/PI(s)) is strongly encouraged to facilitate collaborations among investigators with pulmonary and HIV expertise and basic and clinical research expertise. It is intended that applications will be multi-disciplinary and highly integrated.

The DCC will support collaborative activities among the individual Clinical/Basic sites including support for the Steering Committee and advisory groups, and development, integration, and execution of collaborative protocols and papers.

The DCC will promote sharing of the data, biosamples, and plans. The DCC will be responsible for arranging meetings and conference calls, preparing reports, creating and maintaining a website for the program, implementing a web-based system both for data entry and to coordinate joint project activities, whenever appropriate. The DCC will be responsible for facilitating the sharing and storage of data and specimens.

The DCC will provide leadership for identifying common elements in the individual site specific projects, standardizing definitions, harmonizing data, and developing joint protocols. The DCC will work with the Clinical/Basic research site investigators to ensure that the consent language is appropriate for sharing both data and biospecimens.

The DCC will provide assistance to assure quality control, to provide safety surveillance, and data analysis for collaborative projects.

The DCC will provide an inventory and tracking for collected and banked bio-specimens, and will assist the group with providing language in the consent documents that permits both sharing of samples and data among the investigators, and consent language that permits de-identified biospecimens and linked data to be stored for future use by the wider research community. The DCC will assist the other centers in developing protocols related to the collecting, handling, storing, tracking and submitting biospecimens to a central repository.

The DCC staff must have expertise and experience in data coordination; biostatistics; information technology; bioinformatics; collection, handling and banking of biospecimens; HIV research; clinical pulmonary research; and research on basic pulmonary biology, including immunology, microbiome research and "omics" technology.

Funding Organization
National Heart Lung and Blood Institute
Fund Category
Support Types
Cooperative Agreements
Eligible Organizations
City Agencies
Commercial Organizations
Community Based Organizations
County Agencies
Educational Organizations/Institutions
Federal Government Agencies
IRS 501 (c)(3) Organizations
Nonprofit Organizations
Religious Organizations
State Agencies
Tribal Organizations
Number of Awards Given
1 award
Award Amount Notes
The NHLBI intends to fund one award corresponding to a total of $720,000 for fiscal year 2013, with a total cost commitment of 3.6 million over a 5-year period, but all future year amounts will depend on annual appropriations.
Letter of Intent Date
Application Due Date
Project Start Date
Application Contact Customer Support
Phone: (800) 518-4726
Technical Contact
Hannah H Peavy
Lung Biology and Disease BranchDivision of Lung Diseases
6701 Rockledge Dr. MSC 7952
Bethesda, MD 208927952
Phone: (301) 435-0222
Fax: (301) 480-3557
Fund Duration
5 years.
Clinical Research
HIV Positive Persons
Information Dissemination
Health Facilities Administrators
Information Providers
Application Process
Applicants must download the SF424 (R&R) application package associated with this funding opportunity using the “Apply for Grant Electronically” button in this FOA or following the directions provided at

It is critical that applicants follow the instructions in the SF424 (R&R) Application Guide (, except where instructed in this funding opportunity announcement to do otherwise. Conformance to the requirements in the Application Guide is required and strictly enforced. Applications that are out of compliance with these instructions may be delayed or not accepted for review.
Companion Funding Opportunity: RFA-HL-13-026, U01 Research Project – Cooperative Agreements.
Web Site
Fund Number

Disclaimer: NPIN provides this information as a public service only. The views and information provided about the materials, funding opportunities, and organizations do not necessarily state or reflect those of the U.S. Department of Health and Human Services, CDC, or NPIN. Fund Record #4612

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